The Journal of clinical endocrinology and metabolism

The most recent articles from: J. Clin. Endocrinol. Metab. December 2018

J. Clin. Endocrinol. Metab. · Dec 2018

Case Reports

Complete Kisspeptin Receptor Inactivation Does Not Impede Exogenous GnRH-Induced LH Surge in Humans.

Mutations in the kisspeptin receptor (KISS1R) gene have been reported in a few patients with normosmic congenital hypogonadotropic hypogonadism (nCHH) (OMIM #146110). ⋯ GnRH pulsatile therapy can induce an LH surge in a woman with a mutated KISS1R, which was previously thought to be completely inactivated in vivo.

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