Arzneimittel Forsch
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Arzneimittel Forsch · Jan 1978
Randomized Controlled Trial Clinical Trial[Experimental study on the effect of ephedrine in an anger-provoking situation].
The purpose of this study was to investigate the effects of ephedrine-induced sympathetic arousal on emotional reactions in an anger-provoking situation. The effects of ephedrine were compared with a placebo condition while the effects of the anger-situation were compared to a neutral control situation. 60 male students were randomly assigned to one of the four conditions of the two-factor design. ⋯ Contrary to expectation, ephedrine decreased subjective emotional reactions to the anger-provoking situation rather than increase it. Methodological problems and possible conclusions about the role of sympathetic arousal for emotional reactions are discussed.
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Arzneimittel Forsch · Jan 1978
Comparative StudyInhibition of cholinesterase by epinephrine and norepinephrine.
Acetylcholinesterase and monoamine oxidase were found to be inhibited by each other's substrate. The inhibition of acetylcholinesterase by low concentration of epinephrine or norepinephrine was found to follow first-order reaction kinetics. The constants characterising this inhibition, the bimolecular rate ka (51.8 M-1 min-1 for epinephrine and 15.9 M-1 min-1 for norepinephrine) and the enzyme inhibitor dissociation constant (8.52 mM for epinephrine and 12.2 mM norepinephrine) were determined. The inhibition of acetylcholinesterase by epinephrine was found to be of the mixed type while its inhibition by norepinephrine was of the competitive type.
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Arzneimittel Forsch · Jan 1978
[ECG changes in psychiatric patients under long-term therapy with psychopharmacological drugs (author's transl)].
1726 psychiatric patients, aged 40-69, under permanent hospitalization were examined electrocardiographically. There were few pronounced indications of a relationship between pathological ECG findings and drugs. ECG changes, mainly T-flattening, were rarest among patients treated exclusively with non-tricyclic drugs, and most often among those patients who received tricyclic and non-tricyclic compounds simultaneously. These disturbances appeared more often among women.