Arzneimittel Forsch
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Arzneimittel Forsch · Dec 1993
DNA single strand breaks in peripheral human lymphocytes after anesthesia with isoflurane-nitrous oxide-oxygen.
DNA single strand breaks were determined in peripheral lymphocytes of neurosurgical patients before and after 180 min of general anesthesia with isoflurane (CAS 26675-46-7)-nitrous oxide-oxygen. Immediately after anesthesia, the frequency of DNA single strand-breaks appeared to be significantly enhanced. In the majority of patients the DNA single strand breaks induced was equivalent to the effect of 0.2-0.5 Gray following x-ray radiation of lymphocytes in vitro. ⋯ Then an increase of the frequency of DNA single strand breaks could not be demonstrated any more. The DNA single strand breaks were repaired by cellular repair systems. As DNA repair is regulated genetically, isoflurane-nitrous oxide-oxygen could induce DNA damage in patients with DNA repair defects.
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Arzneimittel Forsch · Dec 1993
Comparative StudyComparative pharmacokinetics of oral dextromethorphan and dextrorphan in the rabbit.
The pharmacokinetics of dextromethorphan (CAS 125-71-3) and its metabolite dextrorphan (CAS 125-73-5) was compared. The drugs were administered orally at the same molar dose of 0.085 mmol/kg. ⋯ The concentrations of 3-hydroxymorphinan were higher after dextromethorphan than dextrorphan. 3-Methoxymorphinan was detectable only 60 and 120 min after dextromethorphan. This work proposes the therapeutic use of dextrorphan instead of its precursor dextromethorphan.
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Arzneimittel Forsch · Dec 1993
Comparative StudyDisposition of the novel anticancer agent vinorelbine ditartrate following intravenous administration in mice, rats and dogs.
1. KW-2307 (vinorelbine ditartrate, CAS71486-22-1) is a new semisynthetic antitumour vinca alkaloid. Its pharmacokinetics, distribution and excretion were investigated following intravenous administration to mice (1.2 mg/kg), rats (0.12 and 1.2 mg/kg) and dogs (0.4 mg/kg). ⋯ The tissue distribution profile of radioactivity in rats was similar after single and repeated administrations. 5. Radioactivity was excreted mainly in faeces (61-73% dose in 48 h and 71-79% dose in 168 h). Biliary excretion accounted for 42.6% dose in rats during 48 h although enterohepatic cycling was probably unimportant.