Pediatr Crit Care Me
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Pediatr Crit Care Me · Jun 2015
Diagnostic and Prognostic Value of Serum Cystatin C in Critically Ill Children With Acute Kidney Injury.
We aimed to evaluate the value of serum cystatin C for detection of acute kidney injury and pediatric Risk, Injury, Failure, Loss, End-Stage Renal Disease categories in critically ill children and to investigate whether serum cystatin C was associated with outcome. ⋯ Cystatin C is an early and accurate biomarker for acute kidney injury and pediatric Risk, Injury, Failure, Loss, End-Stage Renal Disease categories, and it is associated with adverse clinical outcomes in a heterogeneous population of critically ill children.
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Pediatr Crit Care Me · Jun 2015
Detection of Electrographic Seizures by Critical Care Providers Using Color Density Spectral Array After Cardiac Arrest Is Feasible.
To determine the accuracy and reliability of electroencephalographic seizure detection by critical care providers using color density spectral array electroencephalography. ⋯ Determining which post-cardiac arrest patients experience electrographic seizures by critical care providers is feasible after a brief training. There is moderate sensitivity for seizure and status epilepticus detection and a high negative predictive value.
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Pediatr Crit Care Me · Jun 2015
Glucocorticoid Receptor Expression in Peripheral WBCs of Critically Ill Children.
To characterize glucocorticoid receptor expression in peripheral WBCs of critically ill children using flow cytometry. ⋯ Our study suggests that patients with shock and increased severity of illness have lower glucocorticoid receptor expression in CD4 and CD8 lymphocytes. Glucocorticoid receptor expression does not correlate well with cortisol levels. Future studies could focus on studying glucocorticoid receptor expression variability and isoform distribution in the pediatric critically ill population as well as on different strategies to optimize glucocorticoid response.