Pediatr Crit Care Me
-
Pediatr Crit Care Me · Jun 2015
Randomized Controlled Trial Multicenter StudySafety and Efficacy of Sodium Nitroprusside During Prolonged Infusion in Pediatric Patients.
Sodium nitroprusside is a direct-acting vasodilator used to lower blood pressure in the operating room and ICU. The efficacy of sodium nitroprusside has been analyzed in few pediatric randomized trials. This study assesses the efficacy and safety of sodium nitroprusside following at least 12 hours of IV infusion in children. ⋯ Sodium nitroprusside is efficacious in maintaining mean arterial blood pressure control in children following a 12-hour infusion. Although a high proportion of patients were found to have elevated cyanide levels, toxicity was not observed.