British medical bulletin
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British medical bulletin · Sep 2021
ReviewWhy exercise has a crucial role in cancer prevention, risk reduction and improved outcomes.
Exercise is one of several factors known to lower the risk of developing cancer, as well as improve outcomes in patients already diagnosed. People who exercise after cancer have lower rates of cancer complications, treatment toxicities, relapse and improved survival. This review highlights the supportive data and biochemical processes, which explain these potential benefits. ⋯ More robust clinical trial data are needed to substantiate a causal effect of exercise on overall and cancer-specific survival. These studies are ongoing. Research evaluating the most cost-efficient ways of incorporating prehabilitation, adjunct and rehabilitation programmes into routine practice would be helpful to funding bodies and health care strategists.
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British medical bulletin · Sep 2021
Subacromial spacer implantation: an alternative to arthroscopic superior capsular reconstruction. A systematic review.
This systematic review evaluated and compared the use of a subacromial spacer implantation (SSI) with arthroscopic superior capsular repair (ASCR) in the management of massive irreparable rotator cuff tears (MIRCTs) with an assessment of clinical and imaging outcomes. ⋯ The subacromial spacer is a biodegradable implant easily implanted at arthroscopy. It can lead good clinical and imaging outcomes in MIRCTs. Similarly, ASCR can be performed with either an autograft or synthetic allograft transplantation, with satisfactory results. Long-term prospective studies are needed to compare SSI and ASCR to verify their effectiveness.
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British medical bulletin · Sep 2021
ReviewClinical trials in skeletal dysplasia: a paradigm for treating rare diseases.
Genetic skeletal dysplasia conditions (GSDs) account for 5% of all birth defects. Until recently, targeted treatments were only available for select few conditions; 1 however, opportunities arising from developments in molecular diagnostic technologies are now leading to unparalleled therapeutic advances. This review explores current GSD clinical trials, their challenges and the hopes for the future. ⋯ We horizon scan for future clinical trials.
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British medical bulletin · Sep 2021
Meta AnalysisPlacebo effect in pharmacological management of fibromyalgia: a meta-analysis.
The management of fibromyalgia involves a combination of pharmacological and non-pharmacological treatments. ⋯ I, Bayesian network meta-analysis of double-blind randomized clinical trials.
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British medical bulletin · Sep 2021
Meta AnalysisPlatelet-rich plasma versus steroids injections for greater trochanter pain syndrome: a systematic review and meta-analysis.
Greater trochanter pain syndrome (GTPS) is characterized by a persistent and debilitating pain around the greater trochanter. GTPS can be caused by a combination of gluteus medius or minimus tendinopathy, snapping hip or trochanteric bursitis. ⋯ PRP injections are more effective than CCS at approximately 2 years follow-up.