British medical bulletin
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Micro RNAs (miRNAs) are short non-coding RNAs that act primarily in posttranscriptional gene silencing, and are attracting increasing interest in musculoskeletal conditions. ⋯ Intra-articular injection of microRNA-210 in vivo may represent a potential innovative methodology for the management of meniscal injuries. Characterization of the miRNAs expression in the synovial fluid could lead to the development of better early diagnosis and management strategies for meniscal tears.
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British medical bulletin · Apr 2023
ReviewImplementing brief and low-intensity psychological interventions for children and young people with internalizing disorders: a rapid realist review.
Many children fail to receive the mental health treatments they need, despite strong evidence demonstrating efficacy of brief and low-intensity psychological interventions. This review identifies the barriers and facilitators to their implementation. ⋯ Longitudinal studies can identify methods and processes for enhancing long-term implementation and considers ways to monitor and evaluate uptake into routine practice.
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British medical bulletin · Apr 2023
ReviewCancer survivors and adverse work outcomes: associated factors and supportive interventions.
The number of cancer survivors in a working age is rising. An awareness of factors associated with adverse work outcomes, and of supportive interventions, is needed. ⋯ Recent developments are tailored and timely interventions.
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British medical bulletin · Apr 2023
ReviewMethods of assessing value for money of UK-based early childhood public health interventions: a systematic literature review.
Economic evaluation has an important role to play in the demonstration of value for money of early childhood public health interventions; however, concerns have been raised regarding their consistent application and relevance to commissioners. This systematic review of the literature therefore aims to collate the breadth of the existing economic evaluation evidence of these interventions and to identify the approaches adopted in the assessment of value. ⋯ Future resource allocations decisions regarding early childhood public health interventions may benefit from consistency in the evaluative frameworks and health outcomes captured, as well as consistency in approaches to incorporating non-health costs and outcomes, incorporating equity concerns and the use of appropriate time horizons.
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British medical bulletin · Apr 2023
Meta AnalysisDoes femoroacetabular impingement syndrome affect range of motion? A systematic review with meta-analysis.
It is unclear whether femoroacetabular impingement syndrome (FAIS) affect hip range of motion (ROM). ⋯ Further studies are needed to resolve the uncertainty of evidence about ROM restrictions in asymptomatic FAIm compared to healthy controls.