British medical bulletin
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British medical bulletin · Nov 2024
Management of knee osteoarthritis using bone marrow aspirate concentrate: a systematic review.
Knee osteoarthritis (OA) is a common degenerative joint condition and a major cause of disability in the general population. ⋯ BMAC is a valuable source of mesenchymal stem cells, offering potential benefits in attenuating the inflammatory pathway associated with knee OA. Intra-articular injection of BMAC has shown effectiveness in clinical trials improving functional outcomes of knee OA patients. The superiority of BMAC over other orthobiological treatments cannot be assessed because of conflicting results.
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British medical bulletin · Nov 2024
High-volume injections in Achilles tendinopathy: a systematic review.
Achilles tendinopathy (AT) is common, particularly in runners. High-volume injections (HVIs) may be beneficial in the management of AT compared to other conservative management options, including exercise regimens, platelet-rich plasma (PRP) injections, and extracorporeal shockwave therapy. The published research on the effectiveness of HVI in the treatment of AT was evaluated in this systematic review. ⋯ More robust randomized controlled trials, with longer-term follow-ups and homogeneity, are needed to fully establish its efficacy for AT.