British medical bulletin
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British medical bulletin · Jul 2022
Hamstring, bone-patellar tendon-bone, quadriceps and peroneus longus tendon autografts for primary isolated posterior cruciate ligament reconstruction: a systematic review.
Several autografts are available to reconstruct the posterior cruciate ligament (PCL). ⋯ All autografts are viable options for PCL reconstruction, with BTB and hamstring autografts demonstrating superior PROMs. However, further clinical investigations are required to determine the ideal autograft construct.
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British medical bulletin · Jul 2022
ReviewSmall interfering RNAs in the management of human rheumatoid arthritis.
Rheumatoid arthritis (RA) has unclear pathogenesis, but the molecules that feed its inflammatory state are known. Small interfering RNAs (siRNAs) are useful to identify molecular targets and evaluate the efficacy of specific drugs, and can themselves be used for therapeutic purposes. ⋯ To date, it is not possible to determine whether the pharmacological response of siRNAs on cells in vitro would be similar to what takes place in vivo for the diseases studied so far.
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British medical bulletin · Mar 2022
Rotational head acceleration and traumatic brain injury in combat sports: a systematic review.
Traumatic brain injury (TBI) in combat sports is relatively common, and rotational acceleration (RA) is a strong biomechanical predictor of TBI. This review summarizes RA values generated from head impacts in combat sport and puts them in the context of present evidence regarding TBI thresholds. ⋯ Prospective research collecting real-time RA data is required to further understanding of TBI in combat sports.
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British medical bulletin · Mar 2022
Matrix-induced autologous chondrocyte implantation (mACI) versus autologous matrix-induced chondrogenesis (AMIC) for chondral defects of the knee: a systematic review.
Chondral defects of the knee are common and their treatment is challenging. ⋯ AMIC may provide better outcomes than mACI for chondral defects of the knee. Further studies are required to verify these results in a clinical setting.
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Antibiotic resistance raises ethical issues due to the severe and inequitably distributed consequences caused by individual actions and policies. ⋯ Neglected topics include the harms of antibiotic use, including off-target effects on the human microbiome, and the lack of evidence guiding most antibiotic prescription decisions.