British medical bulletin
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British medical bulletin · Sep 2021
ReviewClinical trials in skeletal dysplasia: a paradigm for treating rare diseases.
Genetic skeletal dysplasia conditions (GSDs) account for 5% of all birth defects. Until recently, targeted treatments were only available for select few conditions; 1 however, opportunities arising from developments in molecular diagnostic technologies are now leading to unparalleled therapeutic advances. This review explores current GSD clinical trials, their challenges and the hopes for the future. ⋯ We horizon scan for future clinical trials.
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British medical bulletin · Sep 2021
Meta AnalysisPlacebo effect in pharmacological management of fibromyalgia: a meta-analysis.
The management of fibromyalgia involves a combination of pharmacological and non-pharmacological treatments. ⋯ I, Bayesian network meta-analysis of double-blind randomized clinical trials.
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British medical bulletin · Sep 2021
Meta AnalysisPlatelet-rich plasma versus steroids injections for greater trochanter pain syndrome: a systematic review and meta-analysis.
Greater trochanter pain syndrome (GTPS) is characterized by a persistent and debilitating pain around the greater trochanter. GTPS can be caused by a combination of gluteus medius or minimus tendinopathy, snapping hip or trochanteric bursitis. ⋯ PRP injections are more effective than CCS at approximately 2 years follow-up.
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British medical bulletin · Sep 2021
ReviewThe promise of artificial intelligence: a review of the opportunities and challenges of artificial intelligence in healthcare.
Artificial intelligence (AI) and machine learning (ML) are rapidly evolving fields in various sectors, including healthcare. This article reviews AI's present applications in healthcare, including its benefits, limitations and future scope. ⋯ Regulatory guidelines are needed on how to safely implement and assess AI technology, alongside further research into the specific capabilities and limitations of its medical use.
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A major complication of total hip arthroplasty is dislocation. The hip joint capsule can be incised and repaired, or can be excised. ⋯ Appropriately powered randomized clinical trials should be conducted to better define the association between the chosen implants, approach and outcome.