British medical bulletin
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During the past decades, several rating scales have been developed to assess the functional status of patients with hip pain. ⋯ Although many scoring systems have been used to evaluate hip function, we are still far from a single outcome evaluation system which is reliable, valid and sensitive.
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British medical bulletin · Jun 2019
ReviewNeuroinflammation is a putative target for the prevention and treatment of perioperative neurocognitive disorders.
The demographics of aging of the surgical population has increased the risk for perioperative neurocognitive disorders in which trauma-induced neuroinflammation plays a pivotal role. ⋯ What are the most effective and safest interventions for preventing and/or reversing Perioperative Neurocognitive Disorders.
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British medical bulletin · Jun 2019
MicroRNA in osteoarthritis: physiopathology, diagnosis and therapeutic challenge.
Osteoarthritis (OA) is the most orthopedic condition. The pattern of gene expression and the transcription factors that exert control of chondrogenesis have been extensively studied. ⋯ miRNA could be useful for diagnostic or management purposes, but the issue of delivery of miRNA targeting agents needs to be overcome before miRNA can be applied in clinical practice.
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British medical bulletin · Jun 2019
ReviewHealth impact of climate change in cities of middle-income countries: the case of China.
This review examines the human health impact of climate change in China. Through reviewing available research findings under four major climate change phenomena, namely extreme temperature, altered rainfall pattern, rise of sea level and extreme weather events, relevant implications for other middle-income population with similar contexts will be synthesized. ⋯ The lack of studies on the health implications of rising sea levels and on comorbidity and injury outcomes warrants immediate attention. Evidence is needed to understand health impacts on vulnerable populations living in growing urbanized cities and urban enclaves, in particular migrant workers. Location-specific climate-health outcome thresholds (such as temperature-mortality threshold) will be needed to support evidence-based clinical management plans and health impact mitigation strategies to protect vulnerable communities.