British medical bulletin
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British medical bulletin · Dec 2023
ReviewElevated mortality among the second-generation (children of migrants) in Europe: what is going wrong? A review.
The 'second-generation' (i.e. the children of migrants) represent one of the fastest growing subpopulations of the child and young adult populations in Europe today. The research so far appears to indicate that their mortality risk is elevated relative to people with non-migrant backgrounds. ⋯ Place more emphasis on the complexity of migration background, specific causes-of-death, and understanding the roles of explanatory factors beyond socioeconomic background.
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Participant recruitment to clinical trials is often sub-optimal. Decentralized clinical trials have the potential to address challenges in traditional site-based clinical trial recruitment. ⋯ The focus of development must ensure that the overall impact will widen participation and reduce inequalities in healthcare.
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British medical bulletin · Dec 2023
ReviewSmall interfering RNAs in the management of human osteoporosis.
Osteoporosis results in reduced bone mass and consequent bone fragility. Small interfering RNAs (siRNAs) can be used for therapeutic purposes, as molecular targets or as useful markers to test new therapies. ⋯ Despite the predictability of pharmacological response of siRNA in vitro, similar responses cannot be expected in vivo.
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British medical bulletin · Dec 2023
ReviewInterventions to tackle health inequalities in cardiovascular risks for socioeconomically disadvantaged populations: a rapid review.
Cardiovascular disease (CVD) has shown significant health inequalities for people with low socioeconomic status associated with more risk factors. This review was to synthesize interventions that targeted CVD risks and outcomes among socioeconomically disadvantaged populations and to understand the impact associated with these interventions. ⋯ Research is needed with mixed evidence using real world evaluation and lived experience combined with health economic evaluation, on both mental and physical health outcomes.