Arch Neurol Chicago
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In a series of patients with trigeminal neuralgia (TN) who were treated with radiofrequency electrocoagulation of the gasserian ganglion and retrogasserian rootlets, either alone or with glycerol, 16 patients with TN and multiple sclerosis (TNMS) are compared with 219 patients with TN without MS. Patients with TNMS were younger and more likely to have bilateral facial pain than those with TN alone. Probability of ipsilateral recurrence was calculated on the basis of Kaplan and Meier product-limit estimates and showed no significant differences in the two groups.
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Arch Neurol Chicago · Apr 1987
Case ReportsAkinetic mutism in a bone marrow transplant recipient following total-body irradiation and amphotericin B chemoprophylaxis. A positron emission tomographic and neuropathologic study.
We describe a case of akinetic mutism associated with diffuse cerebral leukoencephalopathy, which developed in a bone marrow transplant recipient following total-body irradiation and amphotericin B chemoprophylaxis. A trial of high-dose bromocriptine did not stimulate purposeful verbal or motor activity. Fluorine 18-fluorodeoxyglucose/positron emission tomographic studies, performed before and during bromocriptine therapy, demonstrated cerebral hypometabolism and treatment-related decreases in regional cerebral blood volume. We conclude that whole-brain or total-body irradiation may increase blood-brain barrier permeability to polyene antibiotics, and that high-dose therapy with dopamine agonists is unlikely to benefit patients with akinetic mutism due to diffuse white-matter lesions.