Arch Neurol Chicago
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Arch Neurol Chicago · Aug 1993
Randomized Controlled Trial Clinical TrialPropranolol and amitriptyline in prophylaxis of migraine. Pharmacokinetic and therapeutic effects.
To determine if the effectiveness of propranolol hydrochloride and amitriptyline hydrochloride are correlated with blood levels and/or with standardized test of pharmacologic effect and to determine which clinical variables are predictors of response to one or the other medication. ⋯ No significant correlations were found between changes in headache score and blood level of drug or change in any of the physiologic measurements. Amitriptyline significantly reduced the severity, frequency, and duration of headache attacks; propranolol reduced the severity of attacks only. Amitriptyline response was correlated with female gender and baseline headaches of shortest duration and of highest frequency. Propranolol response was associated with attacks of greatest duration at baseline and with low pulse rise with exercise at baseline. Nonspecific response was associated with male gender and most frequent headaches by history.
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Arch Neurol Chicago · Aug 1993
Case ReportsAnatomic-radiologic basis of Lhermitte's sign in multiple sclerosis.
To test the presumption that Lhermitte's sign in multiple sclerosis is the result of a lesion in the cervical spinal cord. ⋯ The findings confirm the presumption that a lesion in the posterior columns of the cervical spinal cord is the cause of Lhermitte's sign in multiple sclerosis.