Arch Neurol Chicago
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Arch Neurol Chicago · Dec 1996
Clinical Trial Controlled Clinical TrialAcute treatment of migraine with dihydroergotamine nasal spray. Dihydroergotamine Working Group.
Despite the benefits of antimigraine medications for patients with migraines, parenteral administration of these drugs has certain disadvantages for at-home patient use. ⋯ The present results suggest that intranasal administration of dihydroergotamine represents an important new therapeutic option for migraine sufferers.
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Arch Neurol Chicago · Dec 1996
Clinical TrialUse of intrathecal baclofen in the treatment of patients with dystonia.
Continuous infusion of intrathecal (IT) baclofen is a highly effective standard therapy for severe spasticity of spinal origin. By contrast, there is limited clinical experience regarding the use of IT baclofen in treating patients with dystonia, and little is known regarding the indications for treatment, efficacy, and safety of IT baclofen in this disorder. ⋯ Despite recent reports that have described the benefit in small numbers of patients with dystonia, we concluded that the role of IT baclofen in treating severe dystonia remains uncertain. Intrathecal baclofen may be more effective when dystonia is associated with spasticity or pain. In the present series, we detected no significant difference in the response to IT baclofen in patients with or without spasticity or pain, perhaps owing to the small sample size.