Arch Neurol Chicago
-
Arch Neurol Chicago · Oct 2004
Case ReportsLevetiracetam induces a rapid and sustained reduction of generalized spike-wave and clinical absence.
Levetiracetam (LEV) is a new antiepileptic drug with efficacy in partial-onset seizures. We report a case in which generalized-onset absence seizures responded clinically and electrographically to LEV. ⋯ This case showed a dramatic, rapid effect of LEV discontinuation and reinstitution on generalized spike-wave burst frequency and clinical absence. The effects were independent of reduction of lamotrigine and without change in topiramate doses and occurred in a time course consistent with LEV pharmacokinetics. Levetiracetam may be effective in generalized-onset epilepsy, and randomized, controlled trials are indicated.
-
Arch Neurol Chicago · Oct 2004
Editorial Comment Historical ArticleViral pathogens in multiple sclerosis: an intriguing (hi)story.