Arch Neurol Chicago
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Arch Neurol Chicago · Feb 2007
Comparative StudyDifferentiation between primary lateral sclerosis and amyotrophic lateral sclerosis: examination of symptoms and signs at disease onset and during follow-up.
Motor neuron diseases can affect the upper motor neuron and/or the lower motor neuron. Both amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) are motor neuron diseases, and there is much debate as to whether these are 2 separate disorders or simply 2 points on a continuum. ⋯ Our findings suggest that a patient presenting with spasticity who does not develop wasting within 3 years most likely has PLS.
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Arch Neurol Chicago · Feb 2007
Comparative StudyDeep gray matter perfusion in multiple sclerosis: dynamic susceptibility contrast perfusion magnetic resonance imaging at 3 T.
To assess the presence of perfusion abnormalities in the deep gray matter of patients with relapsing-remitting and primary progressive multiple sclerosis (MS) in comparison with healthy controls and to investigate the impact of perfusion impairment on clinical disability and fatigue. ⋯ The decrease of tissue perfusion in the deep gray matter of patients with MS is associated with the severity of fatigue.