Arch Neurol Chicago
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Arch Neurol Chicago · Nov 1999
Comparative StudyCerebrospinal fluid creatine kinase-BB isoenzyme activity and outcome after subarachnoid hemorrhage.
The brain is rich in creatine kinase-BB isoenzyme activity (CK-BB), which is not normally present in cerebrospinal fluid (CSF). Results of previous studies have shown that CK-BB can be detected in the CSF of patients with aneurysmal subarachnoid hemorrhage (SAH), but whether CK-BB levels correlate with patients' neurologic outcomes is unknown. ⋯ The level of CSF CK-BB may help predict neurologic outcome after SAH.
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Arch Neurol Chicago · Oct 1999
Sympathetic skin response and heart rate variability in patients with Huntington disease.
To examine the autonomic nervous system functions in patients with Huntington disease. ⋯ These results suggest that there is autonomic nervous system dysfunction in patients with Huntington disease.
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Arch Neurol Chicago · Sep 1999
The influence of handedness on the clinical presentation and neuropsychology of Alzheimer disease.
Research on the influence of handedness on the clinical presentation and neuropsychology of Alzheimer disease (AD) is scarce. ⋯ Left-handed patients with AD do not differ from right-handed patients in the severity or pattern of neuropsychological deficits. Left-handedness or some factor associated with it may contribute to the early appearance of cognitive deficits during the development of Alzheimer disease, but may temper the subsequent rate of progression of deficits.
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Arch Neurol Chicago · Aug 1999
ReviewProton magnetic resonance spectroscopy for the diagnosis and management of cerebral disorders.
The use of magnetism in medicine has a long and colorful history since its legendary discovery in the Western world by the shepherd Magnes. More recent use of magnetism has centered on nuclear magnetic resonance. Magnetic resonance spectroscopy (MRS) provides chemical information on tissue metabolites. ⋯ One of the most important contributions of 1H-MRS to clinical neurology is its ability to quantify neuronal loss and to demonstrate reversible neuronal damage. 1H-magnetic resonance spectroscopy has been found to be a useful research tool in elucidating the pathophysiology underlying certain diseases. This review focuses on the use of proton MRS to study various neurologic diseases, including epilepsy, multiple sclerosis, brain tumors, human immunodeficiency virus 1-associated neurologic disorders, as well as cerebrovascular, neurodegenerative, and metabolic diseases. It highlights the contributions of 1H-MRS to the diagnosis and the monitoring of these neurologic diseases that make it a useful adjunct in patient management.
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Arch Neurol Chicago · Jul 1999
Meta AnalysisGlucocorticoids in central nervous system bacterial infection.
To evaluate evidence-based data on adjunctive glucocorticoid therapy in central nervous system bacterial infections. ⋯ Although adjunctive glucocorticoid therapy may be beneficial in both acute bacterial meningitis and more severe tuberculous meningitis, there are conclusive data only for H influenzae meningitis in children. For acute bacterial meningitis, further studies are needed to clarify the optimal duration of dexamethasone therapy (2 vs 4 days), whether this therapy should be used routinely for adults with meningitis, and whether it should be used for pathogens other than H influenzae. For tuberculous meningitis, further studies are needed to provide conclusive evidence of benefit.