Arch Neurol Chicago
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Arch Neurol Chicago · Jul 2002
Meta AnalysisThe role of hypothermia in the management of severe brain injury: a meta-analysis.
Hypothermia is utilized in the management of severe traumatic brain injury despite the lack of unequivocal evidence supporting its use. Because of its widespread use, the effects of hypothermia are a concern. ⋯ This meta-analysis of randomized controlled trials suggests that hypothermia is not beneficial in the management of severe head injury. However, because hypothermia continues to be used to treat these injuries, additional studies are justified and urgently needed.
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Arch Neurol Chicago · Jul 1999
Meta AnalysisGlucocorticoids in central nervous system bacterial infection.
To evaluate evidence-based data on adjunctive glucocorticoid therapy in central nervous system bacterial infections. ⋯ Although adjunctive glucocorticoid therapy may be beneficial in both acute bacterial meningitis and more severe tuberculous meningitis, there are conclusive data only for H influenzae meningitis in children. For acute bacterial meningitis, further studies are needed to clarify the optimal duration of dexamethasone therapy (2 vs 4 days), whether this therapy should be used routinely for adults with meningitis, and whether it should be used for pathogens other than H influenzae. For tuberculous meningitis, further studies are needed to provide conclusive evidence of benefit.