Bmc Neurol
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Randomized Controlled Trial Multicenter Study
Physio4FMD: protocol for a multicentre randomised controlled trial of specialist physiotherapy for functional motor disorder.
Patients with functional motor disorder (FMD) experience persistent and disabling neurological symptoms such as weakness, tremor, dystonia and disordered gait. Physiotherapy is usually considered an important part of treatment; however, sufficiently-powered controlled studies are lacking. Here we present the protocol of a randomised controlled trial (RCT) that aims to evaluate the clinical and cost effectiveness of a specialist physiotherapy programme for FMD. ⋯ This trial will be the first adequately-powered RCT of physical-based rehabilitation for FMD.
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Multicenter Study Observational Study
Non-survivor patients with malignant middle cerebral artery infarction showed persistently high serum malondialdehyde levels.
Previously there have been found higher circulating malondialdehyde levels during the first week of ischemic stroke in patients with worst neurological functional outcome, and at moment of ischemic stroke in non-survivor patients. Thus, the aim of our study was to determine the potential role of serum malondialdehyde levels during the first week of a severe cerebral infarction to mortality prediction. ⋯ The new findings of our study were that serum malondialdehyde levels during the first week of MMCAI could be used as biomarkers to mortality prediction.