Neurol Neurochir Pol
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Neurol Neurochir Pol · Nov 2016
ReviewTargeting of calcitonin gene-related peptide action as a new strategy for migraine treatment.
Migraine is a chronic, recurrent disorder, characterized by attacks of severe pain, affecting around 1% of adult population. Many studies suggest, that trigeminovascular system plays a key role in pathogenesis of migraine and other primary headaches. ⋯ CGRP is and extensively studied peptide as one of the most promising targets in migraine drug research. In the article we focus on the role of CGRP in the pathophysiology of migraine and present current data on CGRP antagonists and CGRP monoclonal antibodies.
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Neurol Neurochir Pol · Nov 2016
Stent-assisted embolization of wide-neck anterior communicating artery aneurysms: Review of consecutive 34 cases.
We report our experience with stent-assisted coiling of anterior communicating artery aneurysms with special consideration of angiographic and clinical outcomes, retreatment rate and periprocedural complications. ⋯ The use of stent is feasible and effective for coil embolization of wide-necked anterior communicating artery aneurysms. Although periprocedural complications resulting in severe morbidity are rare, they should be noted, since in terms of thromboembolic events some of them presumably have a potential to be avoidable.