Neurol Neurochir Pol
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Neurol Neurochir Pol · Nov 2016
ReviewTargeting of calcitonin gene-related peptide action as a new strategy for migraine treatment.
Migraine is a chronic, recurrent disorder, characterized by attacks of severe pain, affecting around 1% of adult population. Many studies suggest, that trigeminovascular system plays a key role in pathogenesis of migraine and other primary headaches. ⋯ CGRP is and extensively studied peptide as one of the most promising targets in migraine drug research. In the article we focus on the role of CGRP in the pathophysiology of migraine and present current data on CGRP antagonists and CGRP monoclonal antibodies.