Clin Lab
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Review Meta Analysis
Prognostic Value of Expression of MicroRNAs in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.
microRNAs are widely involved in a variety of life processes and considered as potential biomarkers of tumor prognosis. A growing number of studies have documented that miRNAs were associated with outcome in NSCLC patients and can act as a prognostic marker. However, existing studies concerning the relationship between miRNAs and outcome in NSCLC patients were contentious and dispersive. Therefore, a systematic metaanalysis to explore the prognostic value of miRNAs on NSCLC patients is urgently needed. ⋯ Our meta-analysis provided the evidence that miR-21, miR-200c, miR-125b, miR-148b, miR-365, miR-124, miR-32, miR-146a, and miR-375 can act as prognostic biomarkers in NSCLC.
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Activated methods of thromboelastometry such as EXTEM and INTEM are routinely used in management of severe bleeding. However, sometimes the patient is bleeding despite the normal values of EXTEM/ INTEM. Non-activated thromboelastometry (NATEM) is the most sensitive to coagulopathy and shows pathologic results in such cases. However, it is necessary to find an appropriate time interval between blood sampling and NATEM analysis as the results are strongly influenced by time. ⋯ Citrated blood sample becomes stable after 20 minutes of storage but the time window between 30 and 60 minutes seems to be more suitable for NATEM analysis in clinical practice.
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The critically ill polytrauma patient continues to be one of the most complex cases in the intensive care unit (ICU). The molecular damage is closely connected with the severe, specific pathophysiological imbalances, such as severe inflammation, infections, hypermetabolism, oxidative stress, and ultimately multiple organ dysfunction syndrome (MODS). ⋯ Furthermore, evaluation, monitoring, and therapy adaptation in this type of patient is closely related to the biochemical and molecular disorders.
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During the course of acute kidney injury (AKI) patients may require renal replacement therapy (RRT). The preferred therapeutic measure for such patients is continuous RRT (CRRT). Anticoagulation is required to prevent clotting of the extracorporeal circuit. The actual KDIGO guidelines recommend citrate as the first line anticoagulant. ⋯ Measuring Ca2+ concentrations could result in an overdosing or underdosing of citrate when using an analytical method which is different to the instrument used initially to achieve the recommended concentrations. If measurement of the new method results in lower Ca2+ concentration and, therefore, reduced anticoagulation by citrate infusion this could lead to more clotting events. Overestimation of the calcium concentration by the new method in the extracorporeal circuit would result in an increased citrate dose delivered to the patient, leading to in vivo hypocalcemia and a pronouncement of citrate induced acid base derangements. Therefore, to monitor Ca2+ concentrations in CRRT during citrate anticoagulation, specific target values for each individual instrument must be established.
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Red cell distribution width (RDW) is associated with mortality in patients with certain diseases. However, the relationship between RDW and burn patients remains unknown. The objective of this study was to evaluate the diagnostic and prognostic performance of RDW. ⋯ RDW can provide useful information about burn severity and outcome. It may be used as a monitoring index for the illness of burn.