Zh Vyssh Nerv Deyat+
-
Zh Vyssh Nerv Deyat+ · Jan 2010
[Effect of selective serotonin reuptake inhibitor fluoxetine on symptoms of depression-like behavior in WAG/Rij rats].
A possibility to correct behavioral symptoms of depression-like behasior in WAG/Rij rats with selective serotonin reuptake inhibitor antidepressant drug fluoxetine was studied. The efficacy of fluoxetine was compared with that of tricyclic antidepressant imipramine. Vehicle-treated WAG/Rij rats compared with the corresponding group of Wistar rats exhibited symptoms of depression-like behavior: a decreased level of exploratory activity and grooming reactions in the open field test, increased immobility in the forced swimming test, and decreased sucrose intake and preference (anhedonia). ⋯ During treatment, worsening ofbehavioral characteristics was seen not only in "normal" Wistar rats but to an even greater degree in "depressive" WAG/Rij rats. Fluoxetine caused worsening of some behavioral characteristics only in "normal" Wistar rats. In "depressive" WAG/Rij rats, the therapeutic effect offluoxetine developed earlier than that of imipramine and was not accompanied by an adverse side effect on behavior of animals.