Zh Vyssh Nerv Deyat+
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Zh Vyssh Nerv Deyat+ · May 2015
[Association between the 5-HTTLPR Polymorphism of Serotonin Transporter Gene and EEG in Young and Postmenopausal Women].
Effect of ovarian steroids on serotonin neurotransmission suggests that the modulating effect of polymorphisms of the serotonin transporter gene on brain activity in women may change with age related changes in hormonal status. Objective of the study was to identify relationships between 5-HTTLPR polymorphism of the serotonin transporter gene and characteristics of baseline EEG in healthy young women (19-35 years, N = 85) and in women in post menopause (55-80 years, N = 44). ⋯ S'/L' genotype was characterized by higher beta 1 rhythm power in elderly compared with young women. These results demonstrate the difference in the neurophysiological mechanisms of age-related changes in brain activity which are associated with the polymorphism of 5-HTTLPR.