The Medical journal of Australia
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Clinical Trial Controlled Clinical Trial
A double-blind trial of perhexiline maleate in the prophylaxis of angina pectoris.
Perhexiline maleate, which has no beta adreno-receptor-blocking activity, has been suggested as an effective prophylactic agent for angina pectoris. The effects of perhexilline were compared with those of placebo by a double-blind crossover trial in seven patients with moderate to severe angina pectoris. Attack rates and glyceryl trinitrate consumption were significantly lower during the perhexilline phase than during the placebo phase of treatment. There was also a mild fall in resting heart rate. Three patients who had failed to respond to beta adrenoreceptor-blocking drugs, and one who had suffered reccurrence of symptoms after coronary artery surgery responded favourably to perhexiline. It thus appears that perhexiline maleate is an effective and potentially valuable agent in this condition.
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This paper concerns the simultaneous occurrence of tumours, a meningioma and intracranial angioma, of diverse histological characteristics. Their clinical radiological and pathological implications are discussed.
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Three hundred subjects undertook a submaximal bicycle ergometry procedure which was terminated at level 19 on the Borg perceived exertion rating scale. The findings indicated that the total work output was an effective reference criterion for each individual. Age and height were considerably more dominant than weight in affecting this output in both sexes. ⋯ Significant changes characteristic of ischaemia occurred in the electrocardiograms of a substantial proportion of subjects, including the apparently well, the proportion being higher in women than in men. There were definite differences between the ranked work load categories. The relative fitness ranking is of value in assessing a variety of factors affecting performance in heterogeneous populations, and also in following population responses to various procedures.
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Cerebellitis as an unusual manifestation of infectious mononucleosis is reported for the first time in Australia. Complete recovery occurred, as has been the rule in previously described cases. The difficulty that may be encountered in early diagnosis is discussed, and screening for infectious mononucleosis is suggested for elusive neurological illnesses. The possible significance of cerebrospinal fluid antibodies is considered.