Minerva cardioangiologica
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Minerva cardioangiologica · Jan 1990
Randomized Controlled Trial Comparative Study Clinical Trial[Sublingually administered captopril versus nifedipine in hypertension emergencies].
Aim of the study was to assess the effectiveness and tolerability of sublingual captopril (SLC) versus sublingual nifedipine (SLN) in treating hypertensive emergencies. During hypertensive crises (systolic blood pressure exceeding 200 mmHg and diastolic blood pressure exceeding 115 mmHg) forty hypertensive patients received either 25 mg of SLC or 10 mg of SLN in a randomized single blind fashion. ⋯ We conclude that both drugs are effective and useful in treating hypertensive emergencies. Anyway we think that in severe forms SLN should be preferred for the shorter time preceding onset of action.
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A retrospective study was undertaken on 178 cases of fatal pulmonary thromboembolism, 86 males and 92 females, in whom major pulmonary emboli were found at autopsies, performed from 1971 to 1988. The 178 cases represent 6.9% from 2569 autopsies. In 43 cases (24.2%) the fatal pulmonary thromboembolism developed after surgery. ⋯ The conditions at risk for fatal pulmonary thromboembolism were orthopedic surgery and radical surgery for malignancy among the surgical patients, and heart diseases and neoplasias among the medical patients. The death by fatal thromboembolism occurred in the 63.5% in the first six hours after onset of symptoms. The data suggest that recognition of those conditions which coexist with pulmonary thromboembolic disease can facilitate early diagnosis, and that when high risk is present antithrombotic prevention is of critical importance.