Minerva cardioangiologica
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Minerva cardioangiologica · Apr 2010
ReviewDiabetes and cardiovascular outcomes: finding the silver lining.
Type 2 diabetes mellitus and cardiovascular disease create a pernicious synergism that now threatens the public health in both developed and developing countries. As such, there has been a concerted therapeutic effort to mitigate the effects of hyperglycemia on adverse cardiovascular outcomes. ⋯ In this review, we will review the evidence that links diabetes to adverse cardiovascular outcomes and will examine the mechanistic evidence whereby hyperglycemia causes cellular damage in experimental models. We will extrapolate from information gleaned from recent clinical trials and discuss a new therapeutic approach that embraces glycemic control, but with less collateral side effects and perhaps by mechanisms that are also cardio-protective.