Minerva medica
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A high incidence of hereditary blood anomalies (particularly Pelger-Huët's congenital granulocytic anomaly and Lepore haemoglobinopathy) is reported in the people of the Sangro Valley (Abruzzo, South Italy). The clinical, haematological, genetic and demographic implications of the high incidence of these pathologies are discussed.
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Cefuroxime (a third-generation cephalosporin) administered parenterally (mostly i.m.) at a dose of 2-4 g/day for 4-16 days (mean 9.26 days) displayed marked antibacterial activity and excellent tolerability when employed in the treatment of variously located acute infections in 120 drug addict out-patients with almost constant pronounced immune depression. The drug is regarded as the antibiotic of choice in the outpatient management of infection episodes in immunodepressed subjects at high risk of infection.