Minerva medica
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A patient with Marfan syndrome and Schoenlein-Henoch purpura is reported. The diagnosis has been possible only by clinical criteria because no laboratory test is available to support the clinical impressions. Possible initial diagnostic confusion with other purpuric disorders is discussed.
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Different factors involved in nosocomial infection and high risk hospital departments are examined. Methods of surveillance of infection in patients, in staff, and monitoring of environment and equipment are settled. The results obtained in environment monitoring and in some kinds of surgical operation are reported. A policy of epidemiological surveillance is proposed.
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Comparative Study
[Clinical course and histopathology of acute oliguric and non-oliguric renal insufficiency].
A retrospective analysis of clinical course and hystopathologic lesions of 23 patients with multiple system organ failure (MSOF) showed that: non-oliguric acute renal failure is more frequent than the oliguric one; the prognosis is severe in both forms; hystopathologic findings are similar. Since acute tubular necrosis during sepsis is characterized by an high incidence of microthrombosis, the prophylactic use of heparin could be justified.
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A high incidence of hereditary blood anomalies (particularly Pelger-Huët's congenital granulocytic anomaly and Lepore haemoglobinopathy) is reported in the people of the Sangro Valley (Abruzzo, South Italy). The clinical, haematological, genetic and demographic implications of the high incidence of these pathologies are discussed.
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Cefuroxime (a third-generation cephalosporin) administered parenterally (mostly i.m.) at a dose of 2-4 g/day for 4-16 days (mean 9.26 days) displayed marked antibacterial activity and excellent tolerability when employed in the treatment of variously located acute infections in 120 drug addict out-patients with almost constant pronounced immune depression. The drug is regarded as the antibiotic of choice in the outpatient management of infection episodes in immunodepressed subjects at high risk of infection.