Arch Med Sci
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Due to the increasing resistance to nucleot(s)ide analogs in patients with chronic hepatitis B, development of new antiviral drugs to eradicate hepatitis B virus is still urgently needed. ⋯ It is worth demonstrating how useful the established cell system is for evaluating antiviral agents and their mechanisms of action.
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In recent years a steady increase in the number of obese people has been observed worldwide. This problem is also increasingly applicable to children and adolescents. In this study, we conducted a meta-analysis of studies carried out in Poland over ten years (2005-2015) which analysed the diet of preschool children and assessed how significantly it affects the prevention of diet-dependent disease. ⋯ Nutrient intake is not compliant with recommendations for this age group and could not only inhibit physical development, but also increase the risk of diet-dependent diseases.
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This study aimed to systemically summarize the present literature about circulating cystatin C (Cys C) levels in type 2 diabetes mellitus (T2DM) and provide a more precise evaluation of Cys C levels in T2DM. ⋯ Overall, our study suggests that patients with T2DM have an elevated circulating Cys C level compared to healthy controls, and it is associated with race, age, gender, study sample size and disease duration. Further investigations are still needed to explore the causal relationship of aberrant Cys C concentrations in T2DM.