Arch Med Sci
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This study examines the feasibility of SilverCloud therapy for anxiety and/or depression. Findings may help determine SilverCloud effectiveness based on patients' profiles. ⋯ This SilverCloud study shows feasibility for participants who had moderate to severe anxiety and/or depression due to social, behavioral, or economic reasons.
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HNF-4α is a member of the steroid hormone receptor family of transcription factors with roles in the development of the liver and the regulation of several critical metabolic pathways, such as glycolysis, drug metabolism, apolipoproteins and blood coagulation. The transcriptional potency of HNF-4α is well known due to its involvement in diabetes and other metabolic diseases. ⋯ We review HNF-4α structure and function, and its role in haematological disorders. We discuss possible novel therapies that are based on targeting HNF-4α.
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This study aimed to investigate the relationship of gene polymorphisms and fat mass (FM) in Chinese population. ⋯ The results suggest that the RASAL1 gene and the PALLD gene might contribute to variability of trunk FM in healthy Chinese Han people. The PTPRS gene is potentially correlated with leg FM. Our findings provide a clue in fat metabolism.
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Sodium is the main cation in the extracellular space. In physiological conditions, sodium concentration in plasma is 135-145 mmol/l. The kidneys play the most important role in the regulation of sodium homeostasis. ⋯ Treatment of hyponatremia depends on the degree and duration (acute or chronic) of hyponatremia as well as presence of clinical symptoms. Too rapid correction of hyponatremia might result in a potentially fatal osmotic demyelinating syndrome. In the present review paper, pathophysiology and management of hyponatremia in patients with arterial hypertension are discussed.
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Previous studies have reported that microRNAs are implicated in the pathogenesis of diabetic nephropathy (DN). In this study, the underlying molecular mechanisms and diagnostic significance of miR-372-3p were investigated in the process of DN. ⋯ miR-372-3p might be a valuable therapeutic target and diagnostic marker for patients with DN.