Arch Med Sci
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A potential way to explain the relationships between sleep disorders and cognitive disorders during menopausal transition is the identification of genetic markers related to changes in cognitive functions, as well as changes in quality of sleep during menopause. The objective was an analysis of the relationship between sleep disorders and cognitive disorders, according to the possessed oestrogen receptor α gene polymorphism (ESR1) in perimenopausal and postmenopausal women. ⋯ The results indicate an important role of oestrogen receptor α gene polymorphism in the modulation of the effect of insomnia on cognitive functions in peri- and postmenopausal women.
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The nanoparticle has become a part of world industry. This substance has been proven as potentially beneficial for its usage as a catalyst and semi-conductor due to its high surface area and the effects of the quantum size effect. It exhibits potential characteristics and would be applied in a wider scope of usage compared to bulk particles because the smaller the size of the particles, the more room for the extent of their usage. Nano titanium dioxide application as semi-conductors together with a catalyst is highly attributed to its high photochemical stability and ability to be produced at a low-cost. The consequence of this - exposure of nano titanium dioxide particles to humans - raises concerns regarding health and safety. Therefore, this research action works designed to offer a thorough analysis of toxicology impacts produced by our own synthesis modified hydrothermal in vitro experiments. ⋯ There is no cytotoxic effect of nanotitania extraction with 0.05% silver in the growth inhibition test with L929 mouse with the exception of the 100 mg/ml extract.
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There is a lot of evidence that suggests that microRNAs (miRs) play an imperative role in the pathogenesis of polycystic ovary syndrome (PCOS). This study was designed to decipher the role of miR-125b in PCOS pathogenesis. ⋯ Since miR-125b controls the proliferation rate of granulosa cells in polycystic ovaries, it might be addressed as a potential therapeutic target for PCOS patients.
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Patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may develop coronavirus disease 2019 (COVID-19). Risk factors associated with death vary among countries with different ethnic backgrounds. We aimed to describe the factors associated with death in Mexicans with confirmed COVID-19. ⋯ In Mexico, highly prevalent chronic diseases are risk factors for death among persons with COVID-19. Indigenous ethnicity is a poorly studied factor that needs more investigation.
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The objective of the study was to characterize the baseline intra-individual and inter-individual variability of immune cell subsets within abdominoplasty skin specimens. ⋯ Our data highlight the importance of including multiple patients and multiple patient samples when designing dermatological studies that utilise abdominoplasty skin.