Bratisl Med J
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Renal transplantation stands out with lower cost advantages in life expectancy, quality of life and especially in the long-term perspective compared to dialysis. Having significant side effects of immunosuppressive drugs in terms of patient and graft survival limits the use of these drugs. A variety of markers are being explored to prolong the renal graft life. One of these molecules, monocide chemoattractant protein (MCP-1) is a marker involved in renal inflammation. The production of MCP-1 was blocked in kidney diseases and the disease was improved. Along with these promising developments, we decided to investigate whether there is a significant relationship between immunosuppressive therapies used in renal transplantation therapy and serum MCP-1 levels. ⋯ Understanding the role of MCP-1 in monocyte homeostasis and the effects of MCP-1 inhibition in kidney disease will help to design better diagnostic and treatment strategies in patients with inflammatory kidney disease (Tab. 2, Fig. 7, Ref. 45).
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This review aimed to discuss mechanisms through which gut microbiota could act as a key modifier of obesity and related metabolic abnormalities. Obesity is a growing health epidemic with an increasing incidence in European countries. ⋯ Probiotic and prebiotic ingredients provide an optimal target for the development of novel functional foods used in the prevention of obesity development as one of risk factors of chronic diseases. Knowledge about prebiotic and probiotic mechanisms of action, and novel functional foods supplemented with probiotics and prebiotics will facilitate their clinical application and development of personalized healthcare strategies (Fig. 1, Ref. 40) Keywords: gut microbiota, obesity, functional foods, nutrition.
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No abstract Keywords.
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Forty-two COVID-19 patients who underwent emergency PCI due to the diagnosis of acute coronary syndrome were included in the study. Mean age was 63±14.76 and males accounted for 81 % (34/42). Contrast-induced acute kidney injury (CI-AKI) was defined as absolute increase in serum creatinine level by 0.3 mg/dL above baseline within 48 hours of contrast exposure. Patients were divided into two groups according to CI-AKI development following coronary angiography. ⋯ Our study results demonstrated that patients suffering from COVID-19 had a high risk of CI-AKI development following coronary angiography (Tab. 1, Ref. 36).
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No abstract Keywords.