Bratisl Med J
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Drug repurposing studies enable shorter routes to the clinic by skipping the steps like in vitro in vivo screening, chemical optimization and toxicological studies. In our study, we investigated the potent anti-cancer effect of Alzheimer's drug Memantine on 4T1 breast cancer cells. ⋯ Memantine inhibited 4T1 breast cancer cell proliferation at significantly lower doses than mostly studied re-purposed drug Metformin. Therefore, we believe that memantine might hold a great promise as a new repositioned drug in cancer treatment and it is our further interest to investigate its effects in vivo (Fig. 3, Ref. 22).
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The study was designed to evaluate the possible adverse effects and consequences of metal oxide nanoparticles used on some major body organ functions and health parameters. ⋯ The present study confirmed the health risks of the use of metal oxide nanoparticles in the medical field without precautions and supervision; and may encourage application of nanoparticles from alternative origins, such as plants, algae, or microorganisms instead (Tab. 5, Fig. 4, Ref. 30) Keywords: nanoparticles, thyroid, parathyroid, kidney, oxidative stress, blood, green, alternative.
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The present study investigated the role of redox balance, inflammation, mitochondrial dysfunction, and apoptosis in Tramadol (Tra)-induced testicular toxicity. ⋯ The present results suggest that Tra exposure may lead to reproductive toxicity due to the loss of the antioxidant defence system, mitochondrial dysfunction, and activation of inflammatory and apoptotic pathways (Tab. 4, Fig. 5, Ref. 63).
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To investigate the protective potential of resveratrol (RES) in blunt hepatic trauma (BHT) by exploring the anti-inflammatory and histopathologic effects as well as modulatory effects on hepatic biomarkers of acute injury, regeneration, apoptosis and survival in a rat model of BHT. ⋯ In conclusion, our findings revealed for the first time that RES exerts promising hepato-ameliorative effects against blunt hepatic injury as evidenced by decreased inflammation scores, parallel with improved hepatic histology, decreased serum transaminase activity as well as enhanced modulatory effect on regenerative and apoptotic processes in RES-treated rats subjected to experimentally-induced blunt hepatic trauma (Tab. 1, Fig. 1, Ref. 37).