Bratisl Med J
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The authors studied quantification of Neisseria gonorrhoeae from the cervicovaginal area of 53 nonpregnant women with gonorrhoea. The variability of the amount of gonococci in cervicovaginal secretion was rather high from 1.0.10(1) to 1.1.10(8) cfu N. gonorrhoeae in 1 ml. Maximum values of N. gonorrhoeae have been found intra menses (from 1.0.10(2) to 3.0.10(8) cfu N. gonorrhoeae in 1 ml). These findings allow the authors to make some, already more or less known, conclusions usable in clinical practice.
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During the ten year period (1981-1990) of detection of Pseudomonas aeruginosa susceptibility towards anti-Pseudomonas antibiotics a decrease in susceptibility towards GEN took place, namely from 91.7% to 80.0%. Susceptibility towards STR, COL and POL has not altered. During the course of five years we recorded a remarkable augmentation in resistance towards the group of 10 new antibiotics NET-by 24.3%, TIC-by 20.6% and AZL-by 18.5%. ⋯ Eight combinations of antibiotics were tested on 100 strains and CTX+GEN was proved to be the most effective combination-synergistic effect on 92.0 strains. The comparison of the effect of CTX+GEN combination on 12 strains implies identical results gained by both, the plate dilution method and the method of detection of lethal effect rate. For the purpose of routinized examinations the dilution micromethod is the most suitable. (Tab. 4, Ref. 19.).
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Verotoxin as a factor of virulence of E. coli strains is involved in the pathogenesis of hemorrhagic colitis, hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura. The most frequent producers of verocytotoxin are E. coli O157:H7 and O157:H-, yet further 57 E. coli serotypes producing verotoxin have been described. The occurrence rate of verocytotoxigenic strains of E. coli is increasing worldwide and should be a matter of concern also in our conditions. (Ref. 56.)
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The preincubation of PMN leukocytes in amniotic fluid obtained at the end of the gestation period resulted in decreased values of phagocytic activity (about 37%), phagocytic index (about 21.5%) and mainly of the candidacidal capacity to C. albicans (about 72%). The level of lysozyme (11.8 +/- 7.2 mg.l-1) and the level of alpha 1-antitrypsin (0.745 +/- 0.53 g.l-1) were also determined in amniotic fluid. The level of alpha 2-macroglobulin and the proteolytic activity at acidic and mildly alkaline pH could not be established by the methods applied. (Fig. 1, Ref. 23.)
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The effect of high frequency (f = 300.min-1) modulated continuous positive airway pressure (CPAP) (0.49 kPa) was compared with that of CPAP without modulation (0.49 kPa) in 24 anesthetized rabbits in experimental respiratory distress syndrome (RDS) and pulmonary edema. RDS was induced by single excessive lavage of the lung on using the impulse and expulse effect of high frequency jet ventilation. Pulmonary edema was elicited by i.v. administration of a mixture of fatty acids. ⋯ Application of CPAP resulted in normalization of blood gases. Modulated CPAP, compared to CPAP without modulation, further decreased paCO2 and increased paO2. The results obtained in experimental models of RDS and pulmonary edema in rabbits show the beneficial effect of high frequency modulated CPAP by pressure oscillation on values of blood gas tension.