Bratisl Med J
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Sepsis is one of the leading causes of death in intensive care units worldwide. Vitamins C and E are natural antioxidants and anti-inflammatory agents. Suppressing the inflammation is an important treatment target because it plays a role in the pathophysiology of sepsis. The purpose of this study was to investigate the effect of vitamins C and E treatment in rats with sepsis-induced lung damage. ⋯ The rats treated either with vitamin C or E showed improved results for sepsis. We think that they can be used as adjuvant therapy for septic patients because of their effectivity and low costs (Tab. 3, Fig. 2, Ref. 27).
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Evaluation of the impact of surgical treatment on malignant transformation (MT) of adult supratentorial infiltrative grade II gliomas (G2G) in a series of chemotherapy and radiotherapy-naïve patients. ⋯ In our series, less extensive resections were associated with a shorter time to MT. Our data support an adoption of techniques enabling extensive G2G resections, such as intraoperative imaging and awake resections, into everyday routine (Tab. 1, Fig. 2, Ref. 40).
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Kidney carcinoma is currently the tenth most diagnosed tumour in women and the sixth in men. It makes up about 4 % of all malignant tumours. In urology, it is the third most common malignant disease. ⋯ Due to the expansion of diagnostic methods and the introduction of new techniques in surgical treatment, the paradigm in the surgical treatment of this disease has changed in recent years. In the case of a detailed study of the intracellular structures in the carcinogenic processes, the more profound knowledge about them can lead to the elimination of the need for surgical resection in future (Tab. 7, Fig. 4, Ref. 51). Text in PDF www.elis.sk Keywords: kidney carcinoma, RCC, biomarkers, diagnostics, surgical treatment.
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Receptors of the large HER family play an important role in breast cancer, which is undergoing a gradual development in connection with biological development, both in the field of diagnostics and therapy. Dimerization of HER-2 with other HER members, such as HER-3, is the biggest driver of tumor cell growth and survival. Numerous studies show that HER-3 gene overexpression correlates with poor prognosis. ⋯ Our results showed amplification of HER-3 (CERB3) in 2 out of a sample of 20 patients with TNBC, and 13 of 20 HER-2‑positive patients. PD-L1 expression was demonstrated in 3 out of 13 HER-3‑positive patients and 2 out of 2 HER-3‑positive TNBC patients. There was a strong correlation between positive HER-3 and PD-L1 TNBC expression (p = Keywords: breast cancer, HER family, overexpression, HER-3, HER-2, PD-L1, TNBC.