Bratisl Med J
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In non-fermenting Gram-negative bacilli (NFGNB) infections, the interaction between the immune system of the host and the bacteria plays a more important role in determining the pathogenesis than the virulence factors of bacteria per se. We aimed to evaluate the sequential changes in the inflammatory response, including the lipid profile, antimicrobial susceptibility, and outcomes in NFGNB ventilator-associated pneumonia (VAP). ⋯ In NFGNB VAP patients, the change relative to antimicrobial resistance was not appreciated in either the systemic inflammatory response or disease severity. MDR NFGNB isolates were not associated with greater mortality in VAP patients. The decrease in serum HDL and increase in PCT on day 4 indicated a poor prognosis (Tab. 5, Fig. 2, Ref. 30).
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Since the first attempts for ventilation, there have been significant changes in terms of the size of devices, ventilation techniques, and technology. In time, invasive methods and huge devices were replaced by non-invasive methods and small and portable devices. Increased use of non-invasive methods was followed by enrichment of literature on the topic. This study aimed to determine the evolution of non-invasive ventilation (NIV) literature and predict future trends. ⋯ NIV technology and new devices are developing day by day. In addition, new areas of use have been defined by doctors. All these bring about new and different studies on NIV. We believe the present study that summarized the history and development of NIV literature will guide the authors who want to study this area (Tab. 4, Fig. 8, Ref. 19).
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The human body possesses an endogenous regeneration system based on stem cells, which may be found in practically every tissue type. They are classified as embryonic stem cells (ESCs) or nonembryonic stem cells (NESCs). Despite its enormous promise, the use of ESCs is presently limited because of ethical and scientific issues. ⋯ Current animal and laboratory investigations are looking into the viability of bringing stem cell therapy into clinical practice for regeneration in muscular dystrophy, intervertebral disc degeneration, cerebral infarctions, and transplantation medicine. This article delves into the many aspects at play, as well as current situation and possible issues with stem cell treatment in patient care and management (Fig. 1, Ref. 86). Keywords: stem cells, tissue engineering, regenerative medicine, stem cell application.
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Historical Article
50th Anniversary of the First Kidney Transplantation in Bratislava.
No abstract Keywords.
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We investigated iron accumulation and the possible mechanisms in the rabbit cerebellum after the exposure to the real GSM and generated radiofrequency electromagnetic fields (RF EMF) using inductively coupled plasma mass spectrometry (ICP MS) and particles induced X-ray emission (PIXE). ⋯ We suggest that the iron accumulation after the exposure to RF ELF is not the result of higher permeability of blood-brain barrier and leaking out of iron from the bloodstream into the brain cells and tissues. It could be the result of an iron actuation and its redistribution in the tissue (Fig. 2, Ref. 86).