Bratisl Med J
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The present study aims to investigate whether elementary lesions detected at the time of the diagnosis, their distribution characteristics, and CT scoring can be predictive of a cytokine storm. ⋯ CT scoring at the time of admission can be used to predict cases that may develop cytokine storm later (Tab. 4, Fig. 2, Ref. 15).
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Thymoquinone (TQ) is the active compound extracted from Nigella sativa which has been reported to possess various pharmacological attributes. This study shows that Thymoquinone (TQ) is an Alzheimer's disease (AD) model cell line on amyloid-beta (Aβ) -induced U87 (human astrocytoma cell line) in β-amyloid (Aβ)-induced in vitro Alzheimer's Disease (AD) model. ⋯ In in vitro experiments, we determined that TQ has a protective effect by increasing antioxidant parameters in the amyloid beta-induced cell line (Fig. 4, Ref. 41). Text in PDF www.elis.sk Keywords: thymoquinone, amyloid-beta, U87, SOD, CAT, caspase-3.
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Deterioration of vascular responses is the crucial event in the initiation of cardiovascular problems in hypertension (HT) and diabetes mellitus (DM). A well-known oral antidiabetic, sitagliptin, has pleiotropic effects besides improving glycemic state in type-2 DM. This study aimed to investigate the therapeutic effect of sitagliptin on blood pressure with previously unassessed parameters of well-known pathophysiological processes and especially at the microRNA (miRNA) level where there are many unknowns. ⋯ Sitagliptin may control comorbidities, especially HT and introduces new targets to alleviate vascular responses. The new knowledge is; sitagliptin may show these effects through microRNAs (Tab. 2, Fig. 6, Ref. 46).
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This review aimed to discuss mechanisms through which gut microbiota could act as a key modifier of obesity and related metabolic abnormalities. Obesity is a growing health epidemic with an increasing incidence in European countries. ⋯ Probiotic and prebiotic ingredients provide an optimal target for the development of novel functional foods used in the prevention of obesity development as one of risk factors of chronic diseases. Knowledge about prebiotic and probiotic mechanisms of action, and novel functional foods supplemented with probiotics and prebiotics will facilitate their clinical application and development of personalized healthcare strategies (Fig. 1, Ref. 40) Keywords: gut microbiota, obesity, functional foods, nutrition.
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AbstractAIMS: Aims: The Coronavirus Disease 2019 (COVID-19) caused not only global pandemic, but it also pointed at unprepared health care systems and countermeasures were introduced under the pressure of urgent circumstances. This review is focused on discussion and critical evaluation of instrumental tools for COVID-19 diagnosis that were developed in the last months.