Gac Med Mex
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Frailty has been related to adverse outcomes, but evidence on its association with the use of health services is still scarce. ⋯ Frailty could be useful in the planning of health services for older adults. On the other hand, its evaluation would allow prioritizing care for those who are at higher risk of adverse outcomes.
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Progressive supranuclear palsy (PSP) is a rare, atypical parkinsonism, characterized by the presence of intracerebral tau protein aggregates and determined by a wide spectrum of clinical features. The definitive diagnosis is postmortem and is identified through the presence of neuronal death, gliosis, and aggregates of the tau protein presented in the form of neurofibrillary tangles (MNF) with a globose appearance in regions such as the subthalamic nucleus, the substantia nigra, and the globus pallidus The findings in ancillary imaging studies, as well as fluids biomarkers, are not sufficient to support diagnosis of PSP but are used to rule out similar pathologies because there are still no specific or validated biomarkers for this disease. ⋯ Cellular models constitute a good tool to determine the molecular mechanisms underlying them. Finally, PSP in Mexico has been little studied, and its diagnosis is often confused with Parkinson's disease, it has a great health and socio-economic impact on patients, their families, and caregivers, which is why it requires further investigation at both a basic and clinical level.
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Suicidal behavior in adolescents is a growing public health problem. Knowing its risk factors is key for reducing it. ⋯ Five mental health problems increased the risk of reporting suicidal behaviors.