Niger J Clin Pract
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Precancerous lesions are the most commonly cited factor in gastric cancer etiology. The sequence of events in intestinal-type gastric carcinogenesis is considered to be chronic gastritis, atrophy, intestinal metaplasia (IM), dysplasia, and carcinoma, respectively. Early diagnosis and treatment of advanced precursor lesions and gastric cancer is possible by identifying and monitoring patients with such premalignant lesions. ⋯ Therefore, it is considered that patients with intestinal metaplasia may be followed up at longer intervals, except for patients with race, ethnicity, incomplete type, extensive involvement, and a family history of gastric cancer.
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Dry eye disease (DED) occurs as a result of an abnormality in tear production, tear consistency, and tear evaporation. ⋯ This study shows a fairly high prevalence of DED among adults in a semi-urban area in Southwest Nigeria. Ophthalmologists and other eye care workers need to be cautious about the DED and offer appropriate treatment options to patients.
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Endodontic irrigants could alter the mechanical properties of root canal dentin, such as its roughness. ⋯ All tested irrigants increased root canal dentin roughness and the effect was time and concentration-dependent. The ultrasonic activation of the disinfection solutions roughened the root dentin surface significantly.
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Suppressor of cytokine signaling 1 (SOCS1) is a prototype molecule of the SOCS family. Alterations in the SOCS1 expression have been reported in human cancers and some studies suggest that SOCS1 might act as a tumor suppressor in carcinogenesis. In the present study, we aimed to evaluate the association of SOCS1 promoter -1478CA/del gene polymorphism detected in DNA isolated from the tissues of patients with colorectal cancer (CRC) for histopathological characteristics and survival. ⋯ The present study examining the association of SOCS1 -1478CA/del gene polymorphism with CRC showed that CRC patients with del/del allele had both significantly shorter PFS and OS versus those with CA/CA or CA/del allele.
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To determine the prevalence and pattern of uncorrected refractive error among staff of a Nigerian university. ⋯ A significant proportion of the staff of this Nigerian university still lives with uncorrected refractive error with its attendant consequences. Regular eye checks should be done by the staff of our universities and effort should be intensified in eye care awareness creation among the populace, including the apparently enlightened communities.