Niger J Clin Pract
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Dental caries is a multifactorial disease with a genetic disposition. ⋯ The loop pattern is associated with lesser incidence of caries, whereas whorl pattern is associated with higher incidence of caries. Dermatoglyphics is a noninvasive method that can be used to identify caries susceptibility and take appropriate prophylactic measures.
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Multicenter Study
Correlating optical coherence tomography biomarkers with visual acuity in nigerian retinitis pigmentosa patients.
Spectral Domain Optical Coherence Tomography (SD-OCT) has been used for imaging retinitis pigmentosa (RP) eyes and provides useful information on microstructural changes. ⋯ This report supports the notion that OCT image reporting on physical retinal structure in RP eyes can be used to predict disease effects on vision. A prospective study to better quantify the degree of structural change and correlate with the degree of functional loss is required for RP gene types in Nigerians and black Africans.
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Endodontic irrigants could alter the mechanical properties of root canal dentin, such as its roughness. ⋯ All tested irrigants increased root canal dentin roughness and the effect was time and concentration-dependent. The ultrasonic activation of the disinfection solutions roughened the root dentin surface significantly.
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Dry eye disease (DED) occurs as a result of an abnormality in tear production, tear consistency, and tear evaporation. ⋯ This study shows a fairly high prevalence of DED among adults in a semi-urban area in Southwest Nigeria. Ophthalmologists and other eye care workers need to be cautious about the DED and offer appropriate treatment options to patients.
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Suppressor of cytokine signaling 1 (SOCS1) is a prototype molecule of the SOCS family. Alterations in the SOCS1 expression have been reported in human cancers and some studies suggest that SOCS1 might act as a tumor suppressor in carcinogenesis. In the present study, we aimed to evaluate the association of SOCS1 promoter -1478CA/del gene polymorphism detected in DNA isolated from the tissues of patients with colorectal cancer (CRC) for histopathological characteristics and survival. ⋯ The present study examining the association of SOCS1 -1478CA/del gene polymorphism with CRC showed that CRC patients with del/del allele had both significantly shorter PFS and OS versus those with CA/CA or CA/del allele.