Niger J Clin Pract
-
Docetaxel (DOC) is the main chemotherapeutic agent for the treatment of advanced metastatic prostate cancer. Docetaxel shows anticancer effects by preventing the depolymerization of microtubules in the cell, therefore preventing cell division. However, the low survival effect of docetaxel has prompted researchers to search for novel therapeutic agents. Fucoidan (FUC) is a sulfated polysaccharide derived from brown algae. It has many bioactivities which makes fucoidan a promising anticancer agent. In this study, the potential anti-tumorigenic and preventive effects of fucoidan with or without docetaxel in prostate cancer were investigated by analyzing different cell death modalities. ⋯ According to the findings of this study, FUC inhibited tumor growth temporally and dimensionally, especially in preventive applications. FUC and FUC+DOC combinations in both treatment groups showed anti-tumorigenic effects. The results of this study suggest that fucoidan is a promising anticancer agent against prostate cancer. FUC can be considered as a preventive or treatment agent in prostate cancer therapy with DOC. Further studies are needed to fully elucidate the mechanism of action of fucoidan in metastatic prostate cancer.
-
Africa has the highest prevalence of hypertension at 46%. Schoolteachers are vulnerable to hypertension due to work-related and general risk factors. Identifying these factors is key to providing interventions. ⋯ Increasing age and BMI are risk factors for hypertension in this study. Health interventions should focus on weight control, especially among older teachers.
-
In the realm of healthcare, particularly after the COVID-19 pandemic, there is a rising trend of sharing videos on YouTube. The increased popularity of these videos among Internet users can be attributed to the captivating nature of visual and auditory data compared to written information. ⋯ Deficiencies in the accuracy and reliability of Internet information were observed, mirroring the findings in our study. Supervision in this regard was often found to be inadequate. We advocate for the evaluation of video appropriateness before sharing on the Internet. We believe that platforms ensuring easy access to accurate information about crucial interventions such as CPR will significantly contribute to improving health literacy.