Pak J Med Sci
-
To evaluate the clinical curative effect of neoadjuvant chemotherapy combined with immunotherapy and its impact on immunological function and the expression of ER, PR, HER-2 and SATB1 in HER-2-positive breast cancer patients. ⋯ Neoadjuvant chemotherapy combined with immunotherapy has significant effect on the treatment of HER-2-positive breast cancer patients. It can result in the significant enhancement of T lymphocyte function, obvious improvement in the negative converse rates of ER, HER-2 and SATB1, and no evident increase in the adverse drug reactions. The proposed therapeutic approach is safe, effective, and have certain clinical value.
-
To analyze the immediate effect of platelet rich plasma, combined with celecoxib, on knee function and pain in patients with knee osteoarthritis. ⋯ Platelet rich plasma combined with celecoxib can promote the recovery of knee function and reduce pain in patients with knee osteoarthritis. This treatment combination also has a high immediate clinical effectiveness but needs further evaluation to find out the long term effects.
-
The main objective of this study was to assess the prevalence of stress, anxiety and depression, among nurses working in a tertiary hospital dedicated to the COVID-19 patients in Sri Lanka. A cross-sectional study was carried out among nurses working at Colombo East Base Hospital. The data was collected using a self-administered questionnaire and DASS-21, a set of three self-report scales designed to measure the negative emotional states of depression, anxiety, and stress over three months from October 2020. ⋯ The system of reporting mental health issues was unfortunately not in place. Staff felt that reporting stress/burnout or anxiety might seem like a negative attribute. Considering the above factors, one would expect more prevalence than we have seen in this study; therefore, we can infer that if mental health is not prioritised in healthcare institutions, then definitely lack of awareness/openness and under-reporting by staff will result in a long-term systemic problem (Suffering in the name of Resilience).
-
Medical education in Vietnam is going through a period of transformation. The number of medical schools is growing with increased enrollment of the students to meet the workforce needs of the country. Simultaneously, there is a need to ensure the quality of medical graduates and that there are mechanisms in place through relevant regulatory bodies. ⋯ There is a consensus among stakeholders that the accreditation of medical education programs will have a potential to drive quality improvement. In this paper, we present a brief overview of the trajectory of accreditation process in Vietnam with recommendations to move forward. The journey ahead will require a coordinated approach from all stakeholders to build an accreditation system, which ensures that quality healthcare, is offered by the workforce in Vietnam.
-
To assess the preparedness of fresh medical graduates to perform the duties of an effective house officer in clinical settings independently. ⋯ Medical graduates are not confident and well prepared to take the responsibility of patient care independently in clinical settings. Reforms in undergraduate curricula regarding skill training, hospital setup and workings and inter-professional education are advocated by young doctors to enhance their competencies for professional life.