Presse Med
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Review Comparative Study
[Renal and cardiovascular effects of non-steroidal anti-inflammatories and selective cox 2 inhibitors].
HYPERKALIEMIA AND RENAL FAILURE: Nonsteroidal anti-inflammatory drugs (NSAIs) may induce hyperkaliemia and renal failure. With regard to these complications, the notion of a risk factor is fundamental. Selective cyclooxygenase-2 inhibitors (Cox-2) do not provide any notable advantages with regard to the incidence of hyperkaliemia and renal failure. ⋯ The salt-water retention is implied in the increase in blood pressure and the decompensation of heart failure. It has been shown that the incidence of oedema and the increase in blood pressure was significantly reduced with celecoxib compared with rofecoxib. This might have a crucial impact on the mean and long term follow-up of cardiovascular risk in these patients.
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Henoch-Schonlein purpura (HSP) is a small vessel leucocytoclastic vasculitis with IGA deposit. Its little known underlying pathogenic mechanism probably involves an auto-immune reaction triggered-off by various antigens and notably bacterial or viral infectious agents. ⋯ The association of a tuberculosis with HSP is very rarely reported in children. The underlying pathogenic mechanisms are not yet clear. It can be triggered-off by tuberculosis or antituberculosis treatment. In our patient, the rapid regression of the symptomatology and pursuit of the treatment without incidents argue against the hypothesis of HSP induced by antituberculosis agents.
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Review
[Congenital hypopituitarism: when should transcription factor gene screenings be performed?].
THE GENETIC ORIGIN INCREASINGLY INCRIMINATED: Congenital pituitary hormone deficiencies represent conditions of hypopituitarism resulting from abnormal pituitary ontogenesis. This group of genetically determined diseases has considerably widened with the development of molecular biology. Many transcription factors playing a role in pituitary development have been identified, and their mutations reported as causes of isolated or multiple pituitary hormone deficiencies. ⋯ Multiple (or combined) pituitary hormone deficiencies result in the concomitant or sequential onset of several anterior pituitary hormone deficiencies. They are due to mutations of transcription factors involved in the early steps of pituitary development (RIEG, HesX1, LHX4, LHX3, Prop1, POU1F1/Pit-1), and are associated with various phenotypes. FOR BETTER MANAGEMENT: Long-term follow-up of these patients and functional studies of the mutations identified in specialized research centers will help to determine phenotype-genotype correlations, hence providing a valuable help to the management of these orphan diseases.
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Comparative Study
[Acute rupture of hydatid cysts in the peritoneum: 17 cases].
Specify the clinical and progressive characteristics of acute rupture of hydatid cysts in the peritoneum. ⋯ The therapeutic progress has improved the prognosis of ruptured hydatid cysts in the peritoneum. Secondary peritoneal hydatidosis is fundamentally enhanced by the delay in diagnosis and treatment and the absence of medical treatment. The optimal strategy is to treat the patients at the non-complicated stage of the hydatid cyst and, above all, prevent the hydatid infestation.