Saudi Med J
-
To perform a meta-analysis for celiac diseases (CD) among at-risk populations in Kingdom of Saudi Arabia (KSA), as well as a comparison with our previously reported meta-analysis in the normal population. ⋯ In March 2018, at King Abdulaziz University, Jeddah, KSA we commenced a retrospective comprehensive database and journal search for CD among at-risk populations in SA. Data from each of the relevant articles were analyzed using the Statistical Package for Social Science Version 20 (Armonk, NY: IBM Corp.). and the comprehensive meta-analysis program (CMA). The collected data were part of a retrospective literature review and analysis. Thus, a written ethical approval was not obtained before commencing the study. Results: Sixteen articles were found covering type-1 diabetes mellitus (DM), short stature (SS), and down syndrome (DS). Ages 1-50 years . The prevalence of seropositive-CD was 15.6% with high heterogeneity (I2=80.353), while prevalence of biopsy-proven CD was 10.6% with high heterogeneity (I2=73.359). Another article reported the CD prevalence in the at-risk population as 18.4% for the seroprevalence and 6.9% for the biopsy-proven CD. Anti-transglutaminase (anti-tTG) was used in 12 studies; in the remaining 4 studies (EMA in 2, ARA with AGA in one and no details given in one study). Conclusion: Both the prevalence of biopsy-proven CD (10.6%) and seroprevalence (15.6%) were higher than those we previously reported in the normal population (1.4% and 2.7%). The female-to-male ratio (1.9/1) of CD patients was the same in normal and at-risk populations in SA. Meta-analysis for prevalence of CD in DM, SS, and DS separately in SA is recommended.
-
We are presenting a monozygotic twin brothers presented at different ages with different presentations. Twin-A presented at age of 18 days with salt losing crisis. Investigations revealed high plasma renin with low-normal aldosterone. ⋯ Both were having unilateral undescended testes. Adrenal hypoplasia congenita (AHC) was suspected after his twin's presentation. Molecular analysis for gene study for both of them revealed adrenal insufficiency, NR0B1 (DAX1) gene mutation. In conclusion, gene analysis is important for the diagnosis of AHC and for genetic counseling.
-
To report robotic partial nephrectomy (RPN) outcomes from a single tertiary hospital in Saudi Arabia. Methods: We retrospectively reviewed consecutive cases of patients undergoing RPN at King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia, between January 2008 and January 2018. The study reports patient's demographics, tumor characteristics, operative details, and perioperative outcomes, using descriptive statistics of median and range values. Results: One hundred and one patients underwent RPN during the study period. Average tumor size was 3 (1.3-6.4) cm and average radius exophytic nearness anterior/posterior location (RENAL) score was 6 (4-10). ⋯ Conversion to open partial nephrectomy occurred in 9 (8.9%) patients, major complications in 3 (3%) patients, positive surgical margins in 5 (5%) patients, and the hospital stay was 4 (2-14) days. A total of 73 (73%) patients achieved a trifecta of freedom from any complication, negative surgical margins, and ischemia time ≤25 minutes. Study limitations included the retrospective design and small cohort size. Conclusions: The initial experience of robotic partial nephrectomy was associated with a surgical outcome comparable to that reported by higher-volume centers.
-
To identify the prevalence of different types of femoral fractures post-motor vehicle accident (MVA) based on fracture location: proximal, middle and distal. ⋯ Prevalence of the femur fracture location varies depending on gender, age, and other factors.
-
To study auditory temporal resolution skills using adaptive auditory tasks designed with a computer-based experimental program, and to provide normative valuesfor gap detection thresholds (GDTs) of young listeners in 3 listening conditions. Methods: The GDTs were established under 3 stimulus conditions: 1) broadband noise (BBN), 2) narrowband noise within-channel (NBN WC) using similar leading and trailing markers centered at 1.0 KHz, and 3) narrowband noise across-channel (NBN AC) with the leading marker centered at 2.0 KHz and the trailing marker centered at 1.0 KHz. In within-subjects design, the GDTs were obtained from 27 normal hearing young Saudi adults at Speech and Hearing Laboratories, Department of Rehabilitation Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia between April 2017 and April 2018. Results: The mean GDTs for the BBN condition was 3.19 millisecsond (msec), NBN WC was 14.53 msec, and NBN AC was 29.71 msec. ⋯ Also, no correlations among the GDTs of the 3 stimulus conditions were found. Conclusion: The present study showed that experimental program is a reliable tool with clinical potential to estimate GDTs across different conditions. Also, the findings of no correlations in the GDTs across stimulus conditions suggest that different processes were involved in the perception of the temporal gap for different stimulus conditions.