Saudi Med J
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Multicenter Study
The interaction between no folic acid supplementation during early pregnancy and preeclampsia increased the risk of preterm birth.
To explore if there is a positive additive interaction between no folic acid (FA) supplementation in early period of pregnancy and preeclampsia which increases the risk of preterm birth (PTB). ⋯ Our multicenter study showed, for the first time, that there was a positive additive interaction between no FA supplementation in early pregnancy and preeclampsia which increased the risk of all PTB, especially iatrogenic PTB.