Masui. The Japanese journal of anesthesiology
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A 30 year-old pregnant woman (36 weeks) had intracranial hemorrhage due to arteriovenous malformation in the left frontal lobe. She underwent an emergency cesarean section under general anesthesia. ⋯ Emergence from anesthesia was uneventful, and no exacerbation of neurological signs and symptoms were recognized. It is important to control hemodynamic changes during anesthesia for a patient with intracranial hemorrhage due to ruptured arteriovenous malformation.
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In malignant hyperthermia (MH) patients, the rate of Ca(2+)-induced Ca2+ release (CICR) from the sarcoplasmic reticulum (SR) has been reported to be enhanced. The effects of amrinone on the Ca(2+)-related functions (CICR, Ca2+ uptake by the SR and Ca2+ sensitivity of the contractile system) of the skeletal muscle were examined using the chemically skinned fiber technique in the extensor digitorum longus of guinea pigs. ⋯ Ca2+ uptake, initial rate of Ca2+ uptake by the SR and Ca2+ sensitivity of the contractile system were not affected at 1 mM of amrinone. These results suggest that amrinone may be clinically safe to use in MH susceptible patients.