Masui. The Japanese journal of anesthesiology
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We monitored bilateral cerebral oxygen saturation and hemoglobin index while the brain received separate perfusion for major vascular surgery. Before surgery, left cerebral oxygen saturation and hemoglobin index were within normal limits but right cerebral oxygen saturation and right hemoglobin index were low. ⋯ No paralysis or any other neurological complications occurred postoperatively. We conclude that such monitoring is useful during and after anesthesia under separate brain perfusion.
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During perioperative period, plasminogen abnormality can result in unusual or unexplained clotting that occurs spontaneously or after minor trauma. However, there has been no report on perioperative anticoagulation therapy and monitoring in patients with hereditary plasminogen abnormality undergoing cardiac surgery. We performed a successful perioperative anticoagulation therapy and monitoring of a patient with hereditary plasminogen abnormality undergoing cardiac surgery. ⋯ When the patient was admitted to ICU, anticoagulation therapy was started immediately. During perioperative period, no episode suggesting thrombosis was observed. In conclusion, we consider that this successful anticoagulation therapy and monitoring during CPB has been achieved by use of Hepcon/HMS.
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[Analysis of postoperative shivering following the deliberate mild hypothermia during neurosurgery].
We induced deliberate mild hypothermia in 96 patients who underwent intracranial operations using a water blanket and a convective device blanket. The lowest temperature measured at the tympanic membrane during mild hypothermia was adjusted to 34.5 degrees C. The patients were divided into two groups in respect to the occurrence of postoperative shivering, and the relationship between the perioperative parameters and the occurrence of postoperative shivering was evaluated. ⋯ Urinary output was significantly larger in SV than in NSV. Tympanic membrane, nasopharyngeal, and rectal temperatures at the end of surgery and nasopharyngeal, rectal, and peripheral temperatures just after the extubation were significantly lower in SV than in NSV. These results suggest that sufficient rewarming of both the core and peripheral temperatures is important to prevent the postoperative shivering following the mild hypothermic therapy in neurosurgical patients, especially in young patients.
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We previously reported that ketamine analgesia in acute pain was produced by the activation of the monoaminergic descending inhibitory system. Recent studies have confirmed that the NMDA receptor antagonists attenuate the hyperalgesia in neuropathic pain. In this study, we investigated the suppressive effects of a clinically available NMDA antagonist, ketamine, and the mechanisms of its effects on neuropathic pain in rats with peripheral mononeuropathy. ⋯ The CCI rats showed increased NE and 5HT concentrations on both ligated and unligated sides of spinal dorsal horn, compared with shamoperated rats. IP ketamine (50 mg.kg-1) in the CCI rats did not boost the spinal NE or 5HT levels. These results indicate that the anti-hyperalgesic effect of ketamine is derived from a direct action on the spinal cord, but not from the activation of monoaminergic descending inhibitory systems.
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Case Reports
[Preanesthetic assessment of a patient with giant negative T waves on ECG following subarachnoid hemorrhage].
Giant negative T waves on ECG are associated with intracranial hemorrhage such as subarachnoid hemorrhage, ischemic heart disease such as subendocardial infarction, myocardial disease and others. They embarrass us in anesthetic management of urgent neurosurgical patients because of the requirement of making differential diagnosis among these diseases accompanying the ECG abnormality. An 80 year old woman undergoing radical clipping for cerebral artery aneurysm showed giant negative T waves on ECG. ⋯ We thought that giant negative T waves were caused by subarachnoid hemorrhage and decided to perform anesthesia and surgery. Circulation during anesthesia and surgery was stable except a transient decrease in blood pressure due to massive hemorrhage during rupture of the aneurysm. We conclude that preanesthetic assessment of cardiac function by echocardiography is useful for anesthetic management of patients with giant negative T waves on ECG undergoing urgent radical operation for cerebral aneurysm.