Pediatric clinics of North America
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This article outlines the up-to-date understanding of the molecular basis of disorders that cause sudden death. Several arrhythmic disorders that cause sudden death have been well-described at the molecular level, including the long QT syndromes and Brugada syndrome; this article reviews the current scientific knowledge of these diseases. Hypertrophic cardiomyopathy, a myocardial disorder that causes sudden death also has been well-studied. Finally, a disorder in which myocardial abnormalities and rhythm abnormalities coexist, arrhythmogenic right ventricular dysplasia, is described.
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Pediatr. Clin. North Am. · Aug 2004
ReviewHerpesviridae infections in newborns: varicella zoster virus, herpes simplex virus, and cytomegalovirus.
Varicella zoster virus (VZV), herpes simplex virus (HSV) and cytomegalovirus (CMV) are all members of the Herpesviridae family. Humans are the only source of infection for these double stranded DNA viruses. Infants may acquire these infections in utero, peripartum, or postnatally, resulting in a variety of clinical syndromes, ranging from asymptomatic infection to severe infection,with high mortality rates and significant long-term morbidity. This article presents the epidemiology, clinical characteristics, treatment,and prevention strategies for VZV, HSV, and CMV infections in infants.
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In 1991, the World Health Organization and the United Nations Children's Fund launched the Baby-Friendly Hospital Initiative. "Baby-Friendly" is a designation that a hospital or birthing site can receive by demonstrating compliance with the "Ten Steps to Successful Breastfeeding." Baby-Friendly is more than a catchy name or a snappy slogan. With Baby-Friendly policies in place, breastfeeding initiation and duration rates increase and infant illness decreases. This article reviews the development of the Baby-Friendly Hospital Initiative, describes the components of the initiative, and evaluates current data that favor the universal implementation of the Baby-Friendly Hospital Initiative.
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The management of pediatric head injuries has evolved over the past decade,and a number of significant advances have been made. Evidence-based guide-lines and algorithms for the management of severe pediatric head injuries have recently been published, and all pediatricians who care for children with severe head injuries should be familiar with these guidelines. It is hoped the guidelines will streamline the clinical management of these children and stimulate future research into the many areas that require further investigation.
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Pediatr. Clin. North Am. · Feb 2004
ReviewObstructive sleep apnea syndrome in children: controversies in diagnosis and treatment.
Obstructive sleep apnea syndrome (OSAS) is a common, under-recognized condition in childhood with significant morbidities if undiagnosed and untreated. The American Academy of Pediatrics recently issued a clinical practice guideline for the diagnosis and management of childhood OSAS. It was accompanied by a comprehensive evidence-based technical report that summarized the available literature supporting the guideline. The current review highlights areas of controversy and uncertainty that limit the development of more definitive standards of practice, updates the reader to several newer publications relevant to diagnosis and treatment of childhood OSAS, and identifies future directions for clinical research.